Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.32 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11074779 | 1.00 | PDE4D (0.36) | PDE4DALDH1A1KDM4EHKDC1TDP1 | |
| SCHEMBL11074777 | 1.00 | PDE4D (0.36) | PDE4DALDH1A1KDM4EHKDC1TDP1 | |
| SCHEMBL9481266 | 1.00 | PDE4D (0.36) | PDE4DALDH1A1KDM4EHKDC1TDP1 | |
| SCHEMBL10883270 | 0.93 | PDE4D (0.31) | PDE4D | |
| SCHEMBL10883120 | 0.93 | PDE4D (0.31) | PDE4D | |
| SCHEMBL9482796 | 0.93 | PTGER2 (0.34) | PDE4DPTGER2 | |
| SCHEMBL10864876 | 0.93 | PDE4D (0.31) | PDE4D | |
| SCHEMBL11076621 | 0.93 | PDE4D (0.31) | PDE4D | |
| SCHEMBL11074840 | 0.93 | PDE4D (0.31) | PDE4D | |
| SCHEMBL9482801 | 0.93 | PTGER2 (0.34) | PDE4DPTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204371-A | Pharmaceutically active 9-chloroprostaglandins | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-04-20 | — | — | US | disclosed |
| US-5079259-A | PHARMACEUTICALLY ACTIVE 9-CHLOROPROSTAGLANDINS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-01-07 | — | — | US | disclosed |
| EP-0081455-B1 | 9-BROMO-PROSTAGLANDIN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL APPLICATIONS | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-04-09 | — | — | EP | disclosed |
| US-4487953-A | 9-Bromoprostaglandins, their preparation, and their use as medicaments | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-12-11 | — | — | US | disclosed |
| US-4444788-A | Pharmaceutically active 9-chloroprostaglandins | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-04-24 | — | — | US | disclosed |
| EP-0081455-A2 | 9-Bromo-prostaglandin derivatives, their preparation and pharmaceutical applications | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-06-15 | — | — | EP | disclosed |