Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL950672 | 1.00 | BACE1 (0.42) | BACE1BACE2ABL1 | |
| SCHEMBL18192862 | 0.86 | BACE1 (0.40) | BACE1BACE2 | |
| SCHEMBL18192806 | 0.86 | BACE1 (0.40) | BACE1BACE2 | |
| SCHEMBL969477 | 0.86 | BACE1 (0.39) | BACE1BACE2 | |
| SCHEMBL2930270 | 0.80 | BACE1 (0.50) | BACE1BACE2 | |
| SCHEMBL2930267 | 0.80 | BACE1 (0.50) | BACE1BACE2 | |
| SCHEMBL2932506 | 0.80 | BACE1 (0.54) | BACE1BACE2 | |
| SCHEMBL2932504 | 0.80 | BACE1 (0.54) | BACE1BACE2 | |
| SCHEMBL949777 | 0.80 | BACE1 (0.51) | BACE1BACE2 | |
| SCHEMBL945847 | 0.80 | BACE1 (0.51) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451793-B1 | BACE INHIBITORS | LILLY CO ELI (US) | 2016-11-02 | — | — | EP | disclosed |
| US-8278441-B2 | BACE inhibitors | ELI LILLY AND COMPANY (US) | 2012-10-02 | — | — | US | disclosed |
| EP-2451793-A1 | BACE INHIBITORS | Eli Lilly and Company (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005738-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-01-13 | — | — | WO | disclosed |