Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 6/20 | 0.54 |
| ▸ | AKT2 | P31751 | 4/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.54 |
| ▸ | PRKACG | P22612 | 4/20 | 0.54 |
| ▸ | PRKACB | P22694 | 4/20 | 0.54 |
| ▸ | PRKCG | P05129 | 4/20 | 0.54 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.54 |
| ▸ | PRKCB | P05771 | 3/20 | 0.54 |
| ▸ | PRKCA | P17252 | 3/20 | 0.54 |
| ▸ | PRKCH | P24723 | 3/20 | 0.54 |
| ▸ | PRKCI | P41743 | 3/20 | 0.54 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9484691 | 1.00 | PRKACA (0.54) | PRKACAAKT2ROCK2PRKACGPRKACB | |
| SCHEMBL9484505 | 0.86 | PRKACA (0.55) | PRKACAAKT2ROCK2PRKACGPRKACB | |
| SCHEMBL9484501 | 0.86 | PRKACA (0.55) | PRKACAAKT2ROCK2PRKACGPRKACB | |
| SCHEMBL9484521 | 0.83 | FLT3 (0.51) | PRKACAAKT2ROCK2PRKACGPRKACB | |
| SCHEMBL9484528 | 0.83 | FLT3 (0.51) | PRKACAAKT2ROCK2PRKACGPRKACB | |
| SCHEMBL9587855 | 0.80 | PRKACA (0.82) | PRKACAAKT2ROCK2PRKACGPRKACB | |
| SCHEMBL9587853 | 0.80 | PRKACA (0.82) | PRKACAAKT2ROCK2PRKACGPRKACB | |
| SCHEMBL17737346 | 0.79 | MEN1 (0.60) | PRKACAAKT2PRKACGPRKACBPRKCG | |
| SCHEMBL9484820 | 0.79 | PRKACA (0.46) | PRKACAAKT2ROCK2PRKACGPRKACB | |
| SCHEMBL9484817 | 0.79 | PRKACA (0.46) | PRKACAAKT2ROCK2PRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5245034-A | Compound having vessel smooth muscle relaxation activity | Hidaka, Kiroyoshi (JP) | 1993-09-14 | — | — | US | disclosed |
| US-5216150-A | Muscle relaxant; enzyme inhibitor and platelet aggutination inhibitor | Hidaka, Hiroyoshi (JP) | 1993-06-01 | — | — | US | disclosed |
| US-5081246-A | Isoquinolino sulfonamino derivatives | Hidaka, Hiroyoshi (JP) | 1992-01-14 | — | — | US | disclosed |