Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.32 |
| ▸ | NMBR | P28336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9488291 | 1.00 | CYP11B1 (0.37) | CYP11B1CYP11B2SIRT2ENPP2RXRA | |
| SCHEMBL9488286 | 1.00 | CYP11B1 (0.37) | CYP11B1CYP11B2SIRT2ENPP2RXRA | |
| SCHEMBL1040045 | 0.85 | CYP11B1 (0.41) | CYP11B1CYP11B2SIRT2ENPP2 | |
| SCHEMBL670904 | 0.82 | CYP11B1 (0.43) | CYP11B1CYP11B2SIRT2ENPP2 | |
| SCHEMBL5682164 | 0.82 | CYP11B1 (0.43) | CYP11B1CYP11B2SIRT2ENPP2FLT3 | |
| SCHEMBL8373202 | 0.79 | CYP11B1 (0.39) | CYP11B1CYP11B2SIRT2ENPP2FLT3 | |
| SCHEMBL28422181 | 0.79 | ADA (0.47) | CYP11B1CYP11B2SIRT2ENPP2 | |
| SCHEMBL693097 | 0.79 | CYP11B1 (0.41) | CYP11B1CYP11B2SIRT2ENPP2NMBR | |
| SCHEMBL1414845 | 0.78 | SIRT2 (0.41) | CYP11B1CYP11B2SIRT2ENPP2NMBR | |
| SCHEMBL1829222 | 0.78 | SIRT2 (0.47) | SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0338939-B1 | HISTAMINE DERIVATIVE, PROCESS FOR HIS PREPARATION AND HIS THERAPEUTIC APPLICATION | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1993-01-27 | — | — | EP | disclosed |
| US-5034539-A | Histamine derivative, process for preparing it and its therapeutic use | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1991-07-23 | — | — | US | disclosed |
| EP-0338939-A1 | Histamine derivative, process for his preparation and his therapeutic application | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1989-10-25 | — | — | EP | disclosed |