SCHEMBL949003

SCHEMBL949003

CN1C=C2C(=O)N(C3CCN(C(=O)[C@H](O)CS(=O)(=O)c4ccc5cc(Cl)ccc5c4)CC3)CN2C1

nearest known ligand 0.66

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.66
F2 P00734 2/20 0.64
F9 P00740 1/20 0.64
PLAT P00750 1/20 0.64
KLKB1 P03952 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL947905 1.00 F10 (0.66) F10F2F9PLATKLKB1
SCHEMBL950595 1.00 F10 (0.66) F10F2F9PLATKLKB1
Hydrochloric Acid SCHEMBL949100 0.99 F10 (0.65) F10F2F9PLATKLKB1
SCHEMBL949851 0.91 F10 (0.53) F10F2F9PLATKLKB1
Hydrochloric Acid SCHEMBL949183 0.91 F10 (0.53) F10F2F9PLATKLKB1
Hydrochloric Acid SCHEMBL950701 0.91 F10 (0.53) F10F2F9PLATKLKB1
SCHEMBL948469 0.90 F10 (0.65) F10F2F9PLATKLKB1
SCHEMBL950188 0.89 F10 (0.62) F10F2F9PLATKLKB1
SCHEMBL948405 0.89 F10 (0.64) F10F2F9PLATKLKB1
SCHEMBL950932 0.89 F10 (0.64) F10F2F9PLATKLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1564213-A1 IMIDAZOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE Takeda Pharmaceutical Company Limited (JP) 2005-08-17 EP claimed
US-20110009389-A1 IMIDAZOLE DERIVATIVE, THEIR PRODUCTION AND USE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-01-13 US disclosed
US-20070004736-A1 Imidazole derivative, process for producing the same, and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-01-04 US disclosed
EP-1564213-A1 IMIDAZOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE Takeda Pharmaceutical Company Limited (JP) 2005-08-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070004736-A1 Imidazole derivative, process for producing the same, and use HRH4, F2, HRH2 F10 545/4885F2 2/4885F9 57/4885
US-20110009389-A1 IMIDAZOLE DERIVATIVE, THEIR PRODUCTION AND USE F2, H1-3, CYC1 F10 490/4885F2 1/4885F9 60/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.