Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 6/20 | 0.42 |
| ▸ | CNR2 | P34972 | 5/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15797510 | 0.85 | DPP4 (0.71) | DPP4LMNAHTTTP53CNR1 | |
| SCHEMBL3470666 | 0.80 | DPP4 (0.73) | DPP4HTTNPSR1KMT2ACYP3A4 | |
| SCHEMBL8278787 | 0.80 | DPP4 (0.73) | DPP4HTTNPSR1KMT2ACYP3A4 | |
| SCHEMBL28195781 | 0.79 | NPSR1 (0.46) | LMNAHTTTP53NPSR1MEN1 | |
| SCHEMBL3669763 | 0.77 | RPS6KB1 (0.49) | LMNATP53KMT2ACYP3A4CYP2D6 | |
| SCHEMBL18598162 | 0.75 | DPP4 (0.57) | DPP4CYP3A4CYP2D6CYP2C19SLC6A4 | |
| SCHEMBL16461973 | 0.75 | RPS6KB1 (0.50) | LMNATP53KMT2ACYP3A4CYP2D6 | |
| SCHEMBL15797721 | 0.73 | MC4R (0.50) | DPP4HTTCYP3A4CYP2D6SLC6A4 | |
| SCHEMBL5104104 | 0.73 | RPS6KB1 (0.43) | DPP4HTTTP53CYP3A4CYP2D6 | |
| SCHEMBL5559565 | 0.73 | SLC6A2 (0.45) | DPP4CYP3A4CYP2D6CYP2C19SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0324791-B1 | ARYL-N-AMINOALKYL-4-(SULFONAMIDO)BENZAMIDES, ANTIARRHYTMIC AGENTS AND COMPOSITIONS THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-03-24 | — | — | EP | disclosed |
| US-4920116-A | ANTIARRHYTHMIA AGENTS | SCHERING A.G. (DE) | 1990-04-24 | — | — | US | disclosed |
| EP-0324791-A1 | ARYL-N-AMINOALKYL-4-(SULFONAMIDO)BENZAMIDES, ANTIARRHYTMIC AGENTS AND COMPOSITIONS THEREOF. | SCHERING AG (DE) | 1989-07-26 | — | — | EP | disclosed |
| WO-1988002362-A1 | ARYL-N-AMINOALKYL-4-(SULFONAMIDO)BENZAMIDES, ANTIARRHYTMIC AGENTS AND COMPOSITIONS THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-04-07 | — | — | WO | disclosed |