Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.51 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949148 | 1.00 | SRD5A2 (0.55) | SRD5A2ALDH1A1KDM4EPKMPTGER3 | |
| SCHEMBL949755 | 0.87 | SRD5A2 (0.52) | SRD5A2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL949756 | 0.87 | SRD5A2 (0.52) | SRD5A2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL946360 | 0.87 | SRD5A2 (0.51) | SRD5A2ALDH1A1KDM4EPKMMEN1 | |
| SCHEMBL946357 | 0.87 | SRD5A2 (0.51) | SRD5A2ALDH1A1KDM4EPKMMEN1 | |
| SCHEMBL8131616 | 0.85 | PTGER3 (0.50) | SRD5A2ALDH1A1KDM4EPKMPTGER3 | |
| SCHEMBL8150530 | 0.85 | PTGER3 (0.50) | SRD5A2ALDH1A1KDM4EPKMPTGER3 | |
| SCHEMBL7246674 | 0.85 | PTGER3 (0.55) | SRD5A2ALDH1A1KDM4EPKMPTGER3 | |
| SCHEMBL7246667 | 0.85 | PTGER3 (0.55) | SRD5A2ALDH1A1KDM4EPKMPTGER3 | |
| SCHEMBL945581 | 0.84 | SRD5A2 (0.51) | SRD5A2ALDH1A1KDM4EPKMPTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |