Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.57 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9494462 | 0.93 | KMT2A (0.59) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL8646167 | 0.92 | KMT2A (0.58) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL8647531 | 0.92 | KMT2A (0.58) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL8646173 | 0.92 | KMT2A (0.58) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL2421988 | 0.87 | KMT2A (0.56) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL9493275 | 0.84 | KMT2A (0.55) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL9264030 | 0.83 | KMT2A (0.54) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL9492494 | 0.82 | CHRM1 (0.56) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL8988223 | 0.82 | KMT2A (0.56) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL11299020 | 0.81 | NSD2 (0.63) | KMT2ACHRM1CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412797-A2 | The therapeutic use of substituted benzenes, formulations thereof and novel substituted benzenes | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | claimed |
| US-5177084-A | 1-Azabicycles, Treating Mental Disorders | MERCK SHARP & DOHME LTD. (GB) | 1993-01-05 | — | — | US | disclosed |
| EP-0492904-A1 | Substituted benzene derivatives for use in the treatment of glaucoma | MERCK SHARP & DOHME LTD. (GB) | 1992-07-01 | — | — | EP | disclosed |
| EP-0412797-A2 | The therapeutic use of substituted benzenes, formulations thereof and novel substituted benzenes | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | disclosed |