Mubritinib

Mubritinib

SCHEMBL94943

FC(F)(F)c1ccc(/C=C/c2nc(COc3ccc(CCCCn4ccnn4)cc3)co2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ERBB2

The experimentally established mechanism targets of Mubritinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ERBB2 known ✓ P04626 20/20 1.00
MINK1 Q8N4C8 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mubritinib SCHEMBL571874 1.00 ERBB2 (1.00) ERBB2MINK1
Mubritinib SCHEMBL6758911 0.99 ERBB2 (0.98) ERBB2MINK1
Mubritinib SCHEMBL6758913 0.99 ERBB2 (0.98) ERBB2MINK1
SCHEMBL6579812 0.97 ERBB2 (0.95) ERBB2MINK1
SCHEMBL6579814 0.97 ERBB2 (0.95) ERBB2MINK1
Mubritinib SCHEMBL6758898 0.95 ERBB2 (0.91) ERBB2MINK1
Mubritinib SCHEMBL6758904 0.95 ERBB2 (0.91) ERBB2MINK1
Mubritinib SCHEMBL6760647 0.94 ERBB2 (0.88) ERBB2MINK1
Mubritinib SCHEMBL6760644 0.94 ERBB2 (0.88) ERBB2MINK1
SCHEMBL5524354 0.92 ERBB2 (0.85) ERBB2MINK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2751 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260137794-A1 LIGAND-DRUG CONJUGATE AND USE THEREOF SYSTIMMUNE INC (US) 2026-05-21 US claimed
US-20260125490-A1 Methods for Determining the Likelihood of Survival and for Predicting Likelihood of Metastasis in Cancer Patients LABORATORY CORPORATION OF AMERICA HOLDINGS (US) 2026-05-07 US claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
US-20260076969-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2026-03-19 US claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
US-12577255-B2 MDM2-based modulators of proteolysis and associated methods of use ARVINAS OPERATIONS, INC. (US) 2026-03-17 US claimed
EP-4704832-A2 BIFUNCTIONAL SMALL MOLECULES TO TARGET THE SELECTIVE DEGRADATION OF CIRCULATING PROTEINS Biohaven Therapeutics Ltd. (VG) 2026-03-11 EP claimed
US-20260060936-A1 INDOLIUM-BASED STABILIZERS OF HYDROPHOBIC DRUGS TECHNION RES & DEV FOUNDATION (IL) 2026-03-05 US claimed
EP-3980777-B1 METHODS FOR MANUFACTURING T CELLS BY DIRECT SORTING AND COMPOSITIONS THEREOF IMMATICS US INC (US) 2026-02-25 EP claimed
US-20260049111-A1 METHODS AND COMPOSITIONS COMPRISING TUMOR SUPPRESSOR GENE THERAPY AND CD122/CD132 AGONISTS FOR THE TREATMENT OF CANCER MULTIVIR INC. (US) 2026-02-19 US claimed
WO-2014175444-A1 ANTI-NLRR1 ANTIBODY 千葉県 (JP) 2014-10-30 WO claimed
US-20040106803-A1 Production method of 1-substituted-1,2,3-triazole derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-06-03 US claimed
US-6716863-B2 TYROSINE KINASE INHIBITORS; ANTITUMOR AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2004-04-06 US claimed
US-20040058956-A1 Pharmaceutical composition having an improved water solubility TAKEDA CHEMICAL INDUSTRIES LTD. (JP) 2004-03-25 US claimed
US-20040053972-A1 Medicinal compositions having improved absorbability TAKEDA CHEMICAL INDUSTRIES LTD. (JP) 2004-03-18 US claimed
EP-1350792-A1 MEDICINAL COMPOSITIONS IMPROVED IN SOLUBLITY IN WATER Takeda Chemical Industries, Ltd. (JP) 2003-10-08 EP claimed
EP-1350793-A1 MEDICINAL COMPOSITIONS HAVING IMPROVED ABSORBABILITY Takeda Chemical Industries, Ltd. (JP) 2003-10-08 EP claimed
EP-1310491-A1 METHOD FOR PRODUCING 1-SUBSTITUTED-1,2,3-TRIAZOLE DERIVATIVE Takeda Chemical Industries, Ltd. (JP) 2003-05-14 EP claimed
US-20030069419-A1 Method for producing 1-substituted-1,2,3- triazole derivative TAKEDA PHARMACEUTICAL COMPANY, LIMITED (JP) 2003-04-10 US claimed
US-20020173526-A1 Heterocyclic compounds their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-11-21 US claimed