Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.75 |
| ▸ | RAD52 | P43351 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | DNM1 | Q05193 | 7/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27900998 | 1.00 | TSHR (0.75) | TSHRRAD52NPSR1DNM1HTT | |
| Bromide SCHEMBL32677448 | 1.00 | TSHR (0.75) | TSHRRAD52NPSR1DNM1HTT | |
| Hydrochloric Acid SCHEMBL9133859 | 0.98 | TSHR (0.77) | TSHRRAD52NPSR1DNM1HTT | |
| Hydrochloric Acid SCHEMBL9133123 | 0.98 | TSHR (0.77) | TSHRRAD52NPSR1DNM1HTT | |
| SCHEMBL4905788 | 0.98 | TSHR (0.77) | TSHRRAD52NPSR1DNM1HTT | |
| Hydrochloric Acid SCHEMBL9130911 | 0.97 | TSHR (0.75) | TSHRRAD52NPSR1DNM1HTT | |
| Bromide SCHEMBL8037977 | 0.97 | TSHR (0.70) | TSHRRAD52NPSR1DNM1HTT | |
| Hydrochloric Acid SCHEMBL9134425 | 0.97 | TSHR (0.75) | TSHRRAD52NPSR1DNM1HTT | |
| Bromide SCHEMBL31748189 | 0.97 | TSHR (0.70) | TSHRRAD52NPSR1DNM1HTT | |
| Hydrochloric Acid SCHEMBL9133559 | 0.95 | TSHR (0.72) | TSHRRAD52NPSR1DNM1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531005-A2 | Micro-emulsions | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-03-10 | — | — | EP | disclosed |