Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7565107 | 0.88 | IDO1 (0.48) | IDO1ALDH1A1KDM4EATMDAO | |
| SCHEMBL17329111 | 0.86 | IDO1 (0.59) | IDO1ALDH1A1KDM4EATMDAO | |
| SCHEMBL121915 | 0.82 | IDO1 (0.55) | IDO1ALDH1A1KDM4EATMDAO | |
| SCHEMBL29560223 | 0.82 | IDO1 (0.55) | IDO1ALDH1A1KDM4EATMDAO | |
| SCHEMBL2089439 | 0.80 | IDO1 (0.53) | IDO1ALDH1A1KDM4EATMDAO | |
| SCHEMBL327569 | 0.78 | IDO1 (0.52) | IDO1ALDH1A1KDM4EATMDAO | |
| SCHEMBL11062283 | 0.78 | IDO1 (0.52) | IDO1ALDH1A1KDM4EATMDAO | |
| SCHEMBL3126891 | 0.78 | IDO1 (0.52) | IDO1ALDH1A1KDM4EATMDAO | |
| SCHEMBL2090315 | 0.78 | IDO1 (0.52) | IDO1ALDH1A1KDM4EATMDAO | |
| SCHEMBL5609142 | 0.78 | IDO1 (0.52) | IDO1ALDH1A1KDM4EATMDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11208405-B2 | Pyrrole derivatives as PLK1 inhibitors | SENTINEL ONCOLOGY LIMITED (GB) | 2021-12-28 | — | — | US | disclosed |
| US-20200247796-A1 | PYRROLE DERIVATIVES AS PLK1 INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2020-08-06 | — | — | US | disclosed |
| US-5202444-A | 1L-1,2:5,6-di-O-cyclohexylidene-chiro-inositol derivatives; intermediates for diols and hydroxycarboxylic acids and esters and antibiotics | THE YOKOHAMA RUBBER CO., LTD. (JP) | 1993-04-13 | — | — | US | disclosed |
| EP-0447645-A1 | Aralkylesulfonyl ureas | BAYER AG (DE) | 1991-09-25 | — | — | EP | disclosed |
| EP-0251775-A2 | Alpha-aryl-alpha-phenylethyl-1H-1,2,4-triazole-1-propanenitriles | ROHM AND HAAS COMPANY (US) | 1988-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247796-A1 | PYRROLE DERIVATIVES AS PLK1 INHIBITORS | PLK1, CDK1, AURKC | IDO1 1099/4885ALDH1A1 3956/4885KDM4E 2037/4885 |
| US-11208405-B2 | Pyrrole derivatives as PLK1 inhibitors | PLK1, CDK1, AURKC | IDO1 1099/4885ALDH1A1 3956/4885KDM4E 2037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.