Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.58 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9498075 | 1.00 | KDM4E (0.58) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL9498134 | 0.93 | KDM4E (0.52) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL9498121 | 0.93 | KDM4E (0.52) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL8856463 | 0.88 | KDM4E (0.63) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL8856673 | 0.86 | KDM4E (0.57) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL9497880 | 0.86 | KDM4E (0.60) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL8856261 | 0.82 | KDM4E (0.53) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL13771852 | 0.81 | KDM4E (0.68) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL9838111 | 0.81 | KDM4E (0.52) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL8856233 | 0.79 | KDM4E (0.50) | KDM4ETP53CYP3A4MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283742-B1 | FATTY ACID AMIDES AS INHIBITORS OF ACYL-COA: CHOLESTEROL ACYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1993-05-26 | — | — | EP | claimed |
| US-4716175-A | INHIBITION OF INTESTINAL ABSORPTION OF CHOLESTEROL | WARNER-LAMBERT COMPANY (US) | 1987-12-29 | — | — | US | claimed |
| US-4743605-A | PREVENT ABSORPTION OF CHOLESTEROL | WARNER-LAMBERT COMPANY (US) | 1988-05-10 | — | — | US | disclosed |
| US-4716175-A | INHIBITION OF INTESTINAL ABSORPTION OF CHOLESTEROL | WARNER-LAMBERT COMPANY (US) | 1987-12-29 | — | — | US | disclosed |