SCHEMBL9498322

SCHEMBL9498322

CCCCCOc1ccc(C#Cc2ccc(CC)cn2)cc1

nearest known ligand 0.50

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ACACB O00763 7/20 0.50
MCHR1 Q99705 2/20 0.47
KDM4E B2RXH2 2/20 0.44
ALDH1A1 P00352 2/20 0.44
HPGD P15428 2/20 0.44
HTT P42858 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
NR5A1 Q13285 1/20 0.43
LTA4H P09960 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9496155 0.99 ACACB (0.49) ACACBMCHR1KDM4EALDH1A1HPGD
SCHEMBL9497365 0.99 ACACB (0.49) ACACBMCHR1KDM4EALDH1A1HPGD
SCHEMBL9494910 0.99 ACACB (0.49) ACACBMCHR1KDM4EALDH1A1HPGD
SCHEMBL9497336 0.97 ACACB (0.52) ACACBMCHR1
SCHEMBL9496258 0.93 ACACB (0.55) ACACBMCHR1KDM4EALDH1A1HPGD
SCHEMBL9496938 0.92 ACACB (0.54) ACACBMCHR1KDM4EALDH1A1HPGD
SCHEMBL9495448 0.92 ACACB (0.54) ACACBMCHR1KDM4EALDH1A1HPGD
SCHEMBL9496622 0.92 ACACB (0.54) ACACBMCHR1KDM4EALDH1A1HPGD
SCHEMBL9496091 0.92 ACACB (0.58) ACACBMCHR1
SCHEMBL9495907 0.90 ACACB (0.54) ACACBMCHR1KDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0306505-B1 ACETYLENE DERIVATIVES AS COMPONENTS OF LIQUID CRYSTAL PHASES MERCK PATENT GmbH (DE) 1993-03-24 EP disclosed
US-5068053-A Liquid crystals for optical apparatus MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1991-11-26 US disclosed