Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.61 |
| ▸ | GAA | P10253 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | TOP2A | P11388 | 5/20 | 0.61 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.61 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172914 | 0.89 | CYP3A4 (0.76) | CYP3A4GAASMN1; SMN2TOP2ATOP2B | |
| SCHEMBL15060571 | 0.86 | CYP3A4 (0.81) | CYP3A4GAASMN1; SMN2TOP2ATOP2B | |
| SCHEMBL16606226 | 0.86 | CYP3A4 (0.81) | CYP3A4GAASMN1; SMN2TOP2ATOP2B | |
| SCHEMBL94972 | 0.86 | CYP3A4 (0.81) | CYP3A4GAASMN1; SMN2TOP2ATOP2B | |
| SCHEMBL12308351 | 0.86 | CYP3A4 (0.81) | CYP3A4GAASMN1; SMN2TOP2ATOP2B | |
| SCHEMBL17816434 | 0.81 | CYP3A4 (0.89) | CYP3A4GAASMN1; SMN2TOP2ATOP2B | |
| SCHEMBL422175 | 0.81 | CYP3A4 (0.89) | CYP3A4GAASMN1; SMN2TOP2ATOP2B | |
| SCHEMBL10061877 | 0.81 | CYP3A4 (0.89) | CYP3A4GAASMN1; SMN2TOP2ATOP2B | |
| SCHEMBL13818627 | 0.81 | CYP3A4 (0.89) | CYP3A4GAASMN1; SMN2TOP2ATOP2B | |
| SCHEMBL15472841 | 0.81 | CYP3A4 (0.89) | CYP3A4GAASMN1; SMN2TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058112-A1 | ANTIBODIES | MERCK SHARP & DOHME CORP. | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058112-A1 | ANTIBODIES | IGF1R, EGFR, ERBB3 | CYP3A4 4577/4885GAA 2191/4885SMN1; SMN2 1795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.