Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | GPR17 | Q13304 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | DBH | P09172 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | CBS | P35520 | 1/20 | 0.30 |
| ▸ | SNCA | P37840 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499247 | 0.85 | KDM4E (0.46) | KDM4EGPR17MAPTPOLB | |
| SCHEMBL9499194 | 0.83 | GPR17 (0.33) | CYP1A2GPR17 | |
| SCHEMBL9499254 | 0.83 | MEN1 (0.44) | MEN1KMT2ACYP1A2CYP2D6HPGD | |
| SCHEMBL9499243 | 0.83 | MEN1 (0.44) | MEN1KMT2ACYP1A2CYP2D6GPR17 | |
| SCHEMBL9500182 | 0.83 | GPR17 (0.32) | KDM4EMEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL9499303 | 0.80 | KDM4E (0.35) | KDM4EALDH1A1GPR17MAPTPOLB | |
| SCHEMBL9452258 | 0.78 | MEN1 (0.51) | MEN1KMT2ACYP1A2CYP2D6HPGD | |
| SCHEMBL9499688 | 0.77 | MEN1 (0.44) | KDM4EMEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL9502853 | 0.74 | GRIN2D (0.35) | KDM4EGPR17MAPTPOLB | |
| SCHEMBL9452334 | 0.74 | KDM4E (0.45) | KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303387-B1 | KYNURENIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | MERCK SHARP & DOHME LTD. (GB) | 1993-04-21 | — | — | EP | claimed |