Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.57 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274851 | 0.98 | MAPK8 (0.60) | MAPK8GAAABCC1GRIK1GRIA2 | |
| SCHEMBL31061416 | 0.98 | MAPK8 (0.60) | MAPK8GAAABCC1GRIK1GRIA2 | |
| SCHEMBL23304334 | 0.96 | MAPK8 (0.54) | MAPK8GAAABCC1GRIK1GRIA2 | |
| SCHEMBL24074130 | 0.93 | GRIK1 (0.58) | MAPK8GAAABCC1GRIK1GRIA2 | |
| SCHEMBL10787690 | 0.89 | MAPK8 (0.52) | MAPK8GAAABCC1GRIK1GRIA2 | |
| SCHEMBL30776204 | 0.85 | GRIK1 (0.52) | MAPK8GAAABCC1GRIK1GRIA2 | |
| SCHEMBL31391653 | 0.85 | GRIK1 (0.49) | MAPK8GAAABCC1GRIK1GRIA2 | |
| SCHEMBL7392417 | 0.84 | TP53 (0.66) | GAAMAPTKDM4EPKMMEN1 | |
| SCHEMBL19657496 | 0.83 | PDE5A (0.51) | MAPK8GAAMAPTKDM4EPKM | |
| SCHEMBL31496804 | 0.83 | PDE5A (0.51) | MAPK8GAAMAPTKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5217982-A | Compounds having antihypertensive properties | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1993-06-08 | — | — | US | disclosed |