SCHEMBL9501973

SCHEMBL9501973

COc1ccc(-c2ccc(-c3nc4ccc(F)cc4c(C(=O)O)c3O)cc2)cc1

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 19/20 0.77
PLA2G2A P14555 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10580105 0.87 DHODH (0.89) DHODH
SCHEMBL10582724 0.87 DHODH (0.71) DHODH
SCHEMBL10582925 0.87 DHODH (1.00) DHODH
SCHEMBL9502210 0.86 DHODH (1.00) DHODH
SCHEMBL10580271 0.86 DHODH (0.84) DHODHPLA2G2A
SCHEMBL9502259 0.84 DHODH (0.55) DHODHPLA2G2A
SCHEMBL3894369 0.83 DHODH (0.95) DHODH
SCHEMBL10582725 0.83 DHODH (1.00) DHODH
SCHEMBL10583047 0.82 DHODH (0.78) DHODH
SCHEMBL10583680 0.79 DHODH (0.74) DHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0305952-B1 SUBSTITUTED 2-PHENYL-4-QUINOLINE-CARBOXYLIC ACIDS AMERICAN CYANAMID COMPANY (US) 1993-06-02 EP claimed
EP-0305952-A1 Substituted 2-phenyl-4-quinoline-carboxylic acids AMERICAN CYANAMID COMPANY (US) 1989-03-08 EP claimed
EP-0305952-A1 Substituted 2-phenyl-4-quinoline-carboxylic acids AMERICAN CYANAMID COMPANY (US) 1989-03-08 EP disclosed