Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 20/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9505820 | 0.92 | DHODH (0.63) | DHODHPDE10A | |
| SCHEMBL27434750 | 0.90 | DHODH (0.60) | DHODHCYP3A4CYP2C8CYP2C9CYP1A2 | |
| SCHEMBL9502241 | 0.89 | DHODH (0.82) | DHODHCYP3A4CYP2C8CYP2C9CYP1A2 | |
| SCHEMBL9502003 | 0.87 | DHODH (0.70) | DHODHPDE10A | |
| SCHEMBL10583075 | 0.85 | DHODH (1.00) | DHODHCYP3A4CYP2C8CYP2C9CYP1A2 | |
| SCHEMBL10582725 | 0.84 | DHODH (1.00) | DHODH | |
| SCHEMBL10582434 | 0.84 | DHODH (1.00) | DHODHCYP3A4CYP2C8CYP2C9CYP1A2 | |
| SCHEMBL10584241 | 0.83 | DHODH (0.76) | DHODHPDE10A | |
| SCHEMBL9501955 | 0.81 | DHODH (0.81) | DHODHCYP3A4CYP2C8CYP2C9CYP1A2 | |
| SCHEMBL8793778 | 0.79 | DHODH (0.58) | DHODHCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305952-B1 | SUBSTITUTED 2-PHENYL-4-QUINOLINE-CARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |
| US-4847381-A | ANTIARTHRITIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0305952-A1 | Substituted 2-phenyl-4-quinoline-carboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |