Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.79 |
| ▸ | MAPT | P10636 | 4/20 | 0.79 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 2/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.79 |
| ▸ | THPO | P40225 | 2/20 | 0.79 |
| ▸ | POLB | P06746 | 1/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.79 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.72 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.72 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.72 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3062760 | 0.96 | CACNA1C (0.78) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11824768 | 0.93 | CACNA1F (0.84) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7414021 | 0.92 | CACNA1B (0.78) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7417834 | 0.92 | CACNA1B (0.78) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11828333 | 0.91 | MEN1 (0.77) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9501241 | 0.90 | MEN1 (0.65) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10589139 | 0.89 | CACNA1C (0.68) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| (R)-Nitrendipine SCHEMBL38973 | 0.89 | HIF1A (1.00) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| (S)-Nitrendipine SCHEMBL120983 | 0.89 | HIF1A (1.00) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| Nitrendipine SCHEMBL15516493 | 0.89 | HIF1A (1.00) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458823-B1 | A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-10-13 | — | — | EP | disclosed |
| US-5245039-A | PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES | BOEHRINGER MANNHEIM ITALIA (IT) | 1993-09-14 | — | — | US | disclosed |
| EP-0383320-A1 | A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1990-08-22 | — | — | EP | disclosed |
| US-3932645-A | CORONARY VASODILATORS, HYPOTENSIVE AGENTS | FARBENFABRIKEN BAYER AG (DT) | 1976-01-13 | — | — | US | disclosed |