SCHEMBL9504944

SCHEMBL9504944

COc1ccc(C(C)(C)C)cc1NC(=O)C(=O)NN

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 4/20 0.56
MEN1 O00255 2/20 0.56
KMT2A Q03164 2/20 0.56
MAPK14 Q16539 1/20 0.55
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
TSHR P16473 1/20 0.53
MAPT P10636 3/20 0.51
RECQL P46063 2/20 0.51
LMNA P02545 1/20 0.51
HSP90AA1 P07900 1/20 0.51
PKM P14618 1/20 0.51
ALDH1A1 P00352 2/20 0.50
KDM4E B2RXH2 1/20 0.50
HPGD P15428 1/20 0.50
POLB P06746 1/20 0.49
MAPK1 P28482 1/20 0.47
PPARG P37231 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9502725 0.85 CYP1A2 (0.55) HTTMEN1KMT2AMAPK14CYP1A2
SCHEMBL903579 0.84 MAPK14 (0.62) HTTMEN1KMT2AMAPK14CYP1A2
SCHEMBL26325651 0.83 MAPK14 (0.59) HTTMEN1KMT2AMAPK14CYP1A2
SCHEMBL26324280 0.82 MAPK14 (0.61) HTTMEN1KMT2AMAPK14CYP1A2
SCHEMBL13947606 0.82 HTT (0.61) HTTMEN1KMT2AMAPK14CYP1A2
SCHEMBL16106825 0.82 HTT (0.61) HTTMEN1KMT2AMAPK14CYP1A2
SCHEMBL14288433 0.78 HTT (0.68) HTTMEN1KMT2AMAPK14CYP1A2
SCHEMBL17705668 0.78 HTT (0.49) HTTMEN1KMT2AMAPK14CYP1A2
SCHEMBL23420775 0.78 HTT (0.54) HTTMEN1KMT2AMAPK14CYP1A2
SCHEMBL14288429 0.78 CYP1A2 (0.63) HTTMEN1KMT2AMAPK14CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0303988-B1 POLYMER BOUND UV STABILIZERS ATOCHEM NORTH AMERICA, INC. (US) 1993-05-12 EP disclosed
US-5206378-A Ultraviolet light stabilizers ELF ATOCHEM NORTH AMERICA, INC. (US) 1993-04-27 US disclosed
EP-0303986-B1 MULTIPURPOSE POLYMER BOUND STABILIZERS ATOCHEM NORTH AMERICA, INC. (US) 1992-07-29 EP disclosed
US-5096974-A Reacting primary amino or hydrazido-substituted stabilizers with maleic anhydride polymers; nonextractable and nonvolatile in polymer blends ATOCHEM NORTH AMERICA, INC. (US) 1992-03-17 US disclosed
US-5096977-A Anhydride polymers ATOCHEM NORTH AMERICA, INC. (US) 1992-03-17 US disclosed
US-4981915-A HYDRAZIDE MODIFIERS ATOCHEM NORTH AMERICA, INC. (US) 1991-01-01 US disclosed
US-4981914-A HYDRAZIDE MODIFIERS ATOCHEM NORTH AMERICA, INC. (US) 1991-01-01 US disclosed
US-4868246-A PRIMARY AMINO OR HYDRAZIDO UV ABSORBERS CHEMICALLY BOUND TO POLYMER ANHYDRIDE GROUPS PENNWALT CORPORATION (US) 1989-09-19 US disclosed
US-4863999-A IMIDES OR AMIC ACIDS OF ANHDRIDE POLYMERS PENNWALT CORPORATION (US) 1989-09-05 US disclosed
EP-0303986-A2 Multipurpose polymer bound stabilizers ATOCHEM NORTH AMERICA, INC. (US) 1989-02-22 EP disclosed
EP-0303988-A2 Polymer bound UV stabilizers ATOCHEM NORTH AMERICA, INC. (US) 1989-02-22 EP disclosed