Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9505017 | 1.00 | HSD17B10 (0.48) | HSD17B10CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9503094 | 0.90 | HSD17B10 (0.52) | HSD17B10CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9503103 | 0.90 | HSD17B10 (0.52) | HSD17B10CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9506194 | 0.87 | ELANE (0.43) | ACE2ELANEMMP3MMP1 | |
| SCHEMBL9506199 | 0.87 | ELANE (0.43) | ACE2ELANEMMP3MMP1 | |
| SCHEMBL7602067 | 0.83 | HSD17B10 (0.45) | HSD17B10ACE2 | |
| SCHEMBL9505110 | 0.78 | HSD17B10 (0.53) | HSD17B10CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9505101 | 0.78 | HSD17B10 (0.53) | HSD17B10CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7507978 | 0.78 | HSD17B10 (0.52) | HSD17B10ACE2MMP1CTSB | |
| SCHEMBL7500014 | 0.77 | HSD17B10 (0.50) | HSD17B10ACE2MMP1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276436-B1 | PHOSPHINIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-16 | — | — | EP | disclosed |
| US-4885283-A | Phosphinic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1989-12-05 | — | — | US | disclosed |