⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3749142 | 0.72 | — | — | |
| SCHEMBL647786 | 0.72 | — | — | |
| SCHEMBL3756517 | 0.72 | — | — | |
| SCHEMBL1148843 | 0.72 | TDP1 (0.40) | — | |
| Potassium SCHEMBL29394450 | 0.69 | — | — | |
| SCHEMBL871200 | 0.67 | TDP1 (0.50) | — | |
| SCHEMBL10473455 | 0.67 | — | — | |
| SCHEMBL9622279 | 0.67 | TDP1 (0.36) | — | |
| SCHEMBL8900116 | 0.67 | TDP1 (0.50) | — | |
| Hydrochloric Acid SCHEMBL6320894 | 0.65 | TDP1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 611 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597401-B2 | Methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof | ALBANY MOLECULAR RESEARCH, INC. (US) | 2020-03-24 | — | — | US | claimed |
| US-20180134724-A1 | METHODS AND INTERMEDIATES FOR THE PREPARATION OF OMACETAXINE AND CEPHALOTAXINE DERIVATIVES THEREOF | CURIA BUFFALO R&D, LLC | 2018-05-17 | — | — | US | claimed |
| EP-2010539-B1 | STEREOSELECTIVE REDUCTION OF A MORPHINONE | NEKTAR THERAPEUTICS (US) | 2017-06-14 | — | — | EP | claimed |
| WO-2016182850-A1 | METHODS AND INTERMEDIATES FOR THE PREPARATION OF OMACETAXINE AND CEPHALOTAXINE DERIVATIVES THEREOF | ALBANY MOLECULAR RESEARCH, INC. (US) | 2016-11-17 | — | — | WO | claimed |
| EP-2147920-B1 | Process for the preparation of quaternary n-alkyl morphinan alkaloid salts | MALLINCKRODT LLC (US) | 2016-08-31 | — | — | EP | claimed |
| US-9415044-B2 | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts | MALLINCKRODT LLC (US) | 2016-08-16 | — | — | US | claimed |
| US-20150164886-A9 | Process for the Preparation of Quaternary N-Alkyl Morphinan Alkaloid Salts | MALLINCKRODT INC. (US) | 2015-06-18 | — | — | US | claimed |
| CN-103073524-B | 4-[4-(substituted phenyl) piperazine piperazinyl-1]-butylcarbamic acid substituted aromatic ester derivative and preparation method thereof | NINGBO INST OF MICROCIRCULATION & HENBANE | 2015-06-10 | — | — | CN | claimed |
| US-20150099773-A1 | PROCESS FOR THE PREPARATION OF QUATERNARY N-ALKYL MORPHINAN ALKALOID SALTS | VTESSE LLC | 2015-04-09 | — | — | US | claimed |
| US-8563726-B2 | Stereoselective reduction of a morphinone | NEKTAR THERAPEUTICS (US) | 2013-10-22 | — | — | US | claimed |
| US-7220871-B2 | Intermediates for the hemisynthesis of taxanes and preparation processes therefor | SOCIETE D'ETUDE ET DE RECHERCHE EN INGENIERIE PHARMACEUTIQUE SERIPHARM (FR) | 2007-05-22 | — | — | US | claimed |
| US-20050222089-A1 | Intermediates for the hemisynthesis of taxanes and preparation processes therefor | CHANTELOUP LUC | 2005-10-06 | — | — | US | claimed |
| US-6825365-B2 | FORMED AS ENANTIOMERS OF CIS-BETA-PHENYLGLYCIDIC ACID/BETA-PHENYLISOSERINE REACT WITH NITRILE COMPOUND VIA RITTER REACTION | NOVASEP (FR) | 2004-11-30 | — | — | US | claimed |
| US-20040220256-A1 | Intermediates for the hemisynthesis of taxanes and preparation processes therefor | CHANTELOUP LUC (FR) | 2004-11-04 | — | — | US | claimed |
| US-20020068833-A1 | Intermediates for the hemisynthesis of taxanes and preparation processes therefor | SOCIETE D'ETUDE ET DE RECHERCHE EN INGENIERIE PHARMACEUTIQUE SERIPHARM | 2002-06-06 | — | — | US | claimed |
| EP-0863887-B1 | INTERMEDIARY COMPOUNDS FOR THE HEMISYNTHESIS OF TAXANES AND PREPARATION PROCESSES THEREFOR | SERIPHARM (FR) | 2002-01-23 | — | — | EP | claimed |
| EP-0863887-A1 | INTERMEDIARY COMPOUNDS FOR THE HEMISYNTHESIS OF TAXANES AND PREPARATION PROCESSES THEREFOR | Societé d'Etude et de Recherche en Ingenierie Pharmaceutique Seripharm (FR) | 1998-09-16 | — | — | EP | claimed |
| WO-1997015562-A1 | INTERMEDIARY COMPOUNDS FOR THE HEMISYNTHESIS OF TAXANES AND PREPARATION PROCESSES THEREFOR | SOCIETE D'ETUDE ET DE RECHERCHE EN INGENIERIE PHARMACEUTIQUE SERIPHARM (FR) | 1997-05-01 | — | — | WO | claimed |
| WO-1994001401-A1 | HERBICIDAL AND INSECTICIDAL 3-BENZOYL-PYRROLIDIN-2,4-DIONE DERIVATES | BAYER AKTIENGESELLSCHAFT (DE) | 1994-01-20 | — | — | WO | claimed |
| EP-0335416-A2 | Modified polyoxytetramethylene glycol and processes for its production | HODOGAYA CHEMICAL CO., LTD. (JP) | 1989-10-04 | — | — | EP | claimed |