SCHEMBL9505594

SCHEMBL9505594

O=C(n1cnc2c(=O)[nH]c(=O)[nH]c21)C(F)(F)[C@H](O)[C@H](O)CO

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PNP P00491 1/20 0.34
PDE2A O00408 17/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8743090 0.79 BLM (0.48) PNP
SCHEMBL9139603 0.79 HPGD (0.41) PNP
SCHEMBL8742956 0.79 BLM (0.48) PNP
SCHEMBL10767396 0.79 MEN1 (0.32) PNP
SCHEMBL8742951 0.79 BLM (0.48) PNP
SCHEMBL6275156 0.72 PNP (0.42) PNP
SCHEMBL28297130 0.72 PNP (0.42) PNP
SCHEMBL8743027 0.71 TYMP (0.40)
SCHEMBL8972502 0.71 GSK3B (0.51)
SCHEMBL8743023 0.71 GSK3B (0.51)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0184365-B1 IMPROVEMENTS IN THE TREATMENT OF TUMORS IN MAMMALS ELI LILLY AND COMPANY (US) 1993-08-04 EP claimed
EP-0184365-A2 Improvements in the treatment of tumors in mammals ELI LILLY AND COMPANY (US) 1986-06-11 EP claimed
EP-0184365-B1 IMPROVEMENTS IN THE TREATMENT OF TUMORS IN MAMMALS ELI LILLY AND COMPANY (US) 1993-08-04 EP disclosed