Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | NT5E | P21589 | 3/20 | 0.37 |
| ▸ | CD99 | P14209 | 1/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.36 |
| ▸ | CHKA | P35790 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9167926 | 0.89 | CDK1 (0.42) | CDK1ADORA3ADORA2AADORA1HSP90B1 | |
| SCHEMBL9141840 | 0.87 | — | — | |
| SCHEMBL8972502 | 0.83 | GSK3B (0.51) | ADORA2AADORA1 | |
| SCHEMBL8743023 | 0.83 | GSK3B (0.51) | ADORA2AADORA1 | |
| SCHEMBL8742970 | 0.83 | GSK3B (0.51) | ADORA2AADORA1 | |
| SCHEMBL8743090 | 0.79 | BLM (0.48) | PDE3APNPLMNASMN1; SMN2 | |
| SCHEMBL9139603 | 0.79 | HPGD (0.41) | PDE3ANT5EPNPLMNASMN1; SMN2 | |
| SCHEMBL8742956 | 0.79 | BLM (0.48) | PDE3APNPLMNASMN1; SMN2 | |
| SCHEMBL8742951 | 0.79 | BLM (0.48) | PDE3APNPLMNASMN1; SMN2 | |
| SCHEMBL8743135 | 0.72 | TET2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0184365-B1 | IMPROVEMENTS IN THE TREATMENT OF TUMORS IN MAMMALS | ELI LILLY AND COMPANY (US) | 1993-08-04 | — | — | EP | claimed |
| EP-0184365-A2 | Improvements in the treatment of tumors in mammals | ELI LILLY AND COMPANY (US) | 1986-06-11 | — | — | EP | claimed |