Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | EYA2 | O00167 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10703274 | 0.98 | TDP1 (0.52) | TDP1ALOX15TSHRCYP2C19BLM | |
| SCHEMBL5521537 | 0.96 | TDP1 (0.56) | TDP1ALOX15TSHRCYP2C19BLM | |
| SCHEMBL14155925 | 0.96 | TDP1 (0.56) | TDP1ALOX15TSHRCYP2C19BLM | |
| SCHEMBL791881 | 0.94 | TDP1 (0.54) | TDP1ALOX15TSHRCYP2C19BLM | |
| SCHEMBL8916352 | 0.89 | TDP1 (0.47) | TDP1ALOX15TSHRCYP2C19BLM | |
| SCHEMBL12153724 | 0.88 | TDP1 (0.65) | TDP1ALOX15TSHRCYP2C19BLM | |
| Caldiamide SCHEMBL1114868 | 0.88 | TDP1 (0.65) | TDP1ALOX15TSHRCYP2C19BLM | |
| SCHEMBL18811949 | 0.88 | TDP1 (0.65) | TDP1ALOX15TSHRCYP2C19BLM | |
| SCHEMBL9505775 | 0.87 | TDP1 (0.41) | TDP1ALOX15TSHRCYP2C19BLM | |
| Water SCHEMBL8533754 | 0.86 | TDP1 (0.62) | TDP1ALOX15TSHRCYP2C19BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436579-B1 | CHELATE COMPOSITIONS | NYCOMED SALUTAR, INC. (US) | 1993-08-04 | — | — | EP | claimed |