SCHEMBL9506529

SCHEMBL9506529

CCCCCc1c(F)c(F)c(-c2c(F)c(F)c(F)c(F)c2F)c(F)c1F

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.35
GCGR P47871 10/20 0.33
TYMP P19971 3/20 0.33
TSHR P16473 1/20 0.32
THRB P10828 1/20 0.32
CYP3A4 P08684 1/20 0.31
PTGS2 P35354 1/20 0.31
ALOX5 P09917 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10336354 0.98 TSHR (0.36) CYP19A1GCGRTYMPTSHRTHRB
SCHEMBL9503325 0.98 TSHR (0.36) CYP19A1GCGRTYMPTSHRTHRB
SCHEMBL9503320 0.98 TSHR (0.36) CYP19A1GCGRTYMPTSHRTHRB
SCHEMBL9503366 0.98 TSHR (0.36) CYP19A1GCGRTYMPTSHRTHRB
SCHEMBL9503180 0.93 NPC1 (0.35) GCGRTYMP
SCHEMBL10446746 0.93 CYP19A1 (0.38) CYP19A1GCGRTYMPTSHRTHRB
Hexane SCHEMBL27851252 0.93 CYP19A1 (0.38) CYP19A1GCGRTYMPTSHRTHRB
SCHEMBL28164639 0.90 TSHR (0.42) CYP19A1TYMPTSHRTHRBCYP3A4
SCHEMBL1687611 0.90 TSHR (0.42) CYP19A1TYMPTSHRTHRBCYP3A4
SCHEMBL9505791 0.87 ESR1 (0.40) CYP19A1GCGRTSHRCYP3A4PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0364548-B1 OCTAFLUOROBIPHENYLS MERCK PATENT GmbH (DE) 1993-06-09 EP disclosed