Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 13/20 | 0.66 |
| ▸ | CYSLTR1 | Q9Y271 | 13/20 | 0.66 |
| ▸ | RXRA | P19793 | 3/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9560076 | 0.91 | CYSLTR2 (0.64) | CYSLTR2CYSLTR1RXRANR1H2NR1H3 | |
| SCHEMBL9506696 | 0.80 | CYSLTR2 (0.71) | CYSLTR2CYSLTR1RXRANR1H2NR1H3 | |
| SCHEMBL10482165 | 0.80 | CYSLTR2 (1.00) | CYSLTR2CYSLTR1 | |
| SCHEMBL9560085 | 0.77 | CYSLTR2 (0.79) | CYSLTR2CYSLTR1RXRANR1H2NR1H3 | |
| SCHEMBL10811066 | 0.75 | CYSLTR2 (0.70) | CYSLTR2CYSLTR1RXRANR1H2NR1H3 | |
| SCHEMBL9560077 | 0.75 | CYSLTR2 (0.69) | CYSLTR2CYSLTR1RXRANR1H2NR1H3 | |
| SCHEMBL9505621 | 0.75 | CYSLTR2 (0.58) | CYSLTR2CYSLTR1RXRANR1H2NR1H3 | |
| SCHEMBL10482092 | 0.74 | CYSLTR2 (0.84) | CYSLTR2CYSLTR1 | |
| SCHEMBL10425667 | 0.72 | CYSLTR2 (0.65) | CYSLTR2CYSLTR1RXRANR1H2NR1H3 | |
| SCHEMBL9506708 | 0.70 | CYSLTR2 (0.52) | CYSLTR2CYSLTR1RXRANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375348-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-23 | — | — | EP | disclosed |
| US-4954513-A | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-09-04 | — | — | US | disclosed |
| EP-0375348-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | disclosed |