Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.46 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL1846249 | 0.95 | CA4 (0.50) | CA4FAHD1CA1CA2CA9 | |
| Bicarbonate SCHEMBL6898494 | 0.95 | — | — | |
| Bicarbonate SCHEMBL17475470 | 0.91 | CA4 (0.46) | CA4FAHD1CA1CA2CA9 | |
| Bicarbonate SCHEMBL10575003 | 0.91 | CA4 (0.46) | CA4FAHD1CA1CA2CA9 | |
| Bicarbonate SCHEMBL9010920 | 0.91 | CA1 (0.56) | CA4FAHD1CA1CA2CA9 | |
| Bicarbonate SCHEMBL17309684 | 0.91 | CA1 (0.56) | CA4FAHD1CA1CA2CA9 | |
| Bicarbonate SCHEMBL163255 | 0.91 | CA1 (0.56) | CA4FAHD1CA1CA2CA9 | |
| Bicarbonate SCHEMBL7762411 | 0.91 | CA1 (0.56) | CA4FAHD1CA1CA2CA9 | |
| Bicarbonate SCHEMBL1919132 | 0.91 | CA1 (0.56) | CA4FAHD1CA1CA2CA9 | |
| Bicarbonate SCHEMBL18042414 | 0.91 | CA1 (0.56) | CA4FAHD1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0356176-B1 | ACETAMIDE COMPOUNDS | HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD. (JP) | 1993-09-22 | — | — | EP | disclosed |