Butyrolactone

Butyrolactone

SCHEMBL9507414

CCCC.O=C1CCCO1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.64
CA9 Q16790 1/20 0.64
LMNA P02545 2/20 0.48
ALDH1A1 P00352 1/20 0.48
TP53 P04637 1/20 0.48
TSHR P16473 1/20 0.48
CYP1A2 P05177 3/20 0.38
CYP2D6 P10635 1/20 0.33
SIRT2 Q8IXJ6 1/20 0.33
ATM Q13315 2/20 0.32
PIK3CD O00329 1/20 0.31
CYP2C9 P11712 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butane SCHEMBL28784881 0.93 CA1 (0.76) CA1CA9LMNAALDH1A1TP53
Butane SCHEMBL28137088 0.91 CA1 (0.73) CA1CA9LMNAALDH1A1TP53
Butyrolactone SCHEMBL28864371 0.89 CA1 (0.56) CA1CA9LMNAALDH1A1TP53
Butyrolactone SCHEMBL10420051 0.88
Butyrolactone SCHEMBL27720055 0.87 CA1 (0.82) CA1CA9LMNAALDH1A1TP53
Butyrolactone SCHEMBL29433925 0.87
SCHEMBL19638361 0.87 CA1 (0.82) CA1CA9LMNAALDH1A1TP53
Butyrolactone SCHEMBL9421121 0.87
Butyrolactone SCHEMBL1271043 0.87 CA1 (0.82) CA1CA9LMNAALDH1A1TP53
Butyrolactone SCHEMBL13481 0.87

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0376882-B1 HETEROATOM CONTAINING PERFLUOROALKYL TERMINATED NEOPENTYL ACIDS AND SALTS THEREOF CIBA-GEIGY AG (CH) 1993-08-11 EP disclosed
EP-0376882-A1 Heteroatom containing perfluoroalkyl terminated neopentyl acids and salts thereof CIBA-GEIGY AG (CH) 1990-07-04 EP disclosed
WO-1988000581-A1 PREPARATION OF CARBOXYPROPYLATED NON-IONIC SURFACTANTS GAF CORPORATION (US) 1988-01-28 WO disclosed
US-4720578-A Preparation of fluorinated carboxypropylated non-ionic surfactants GAF CORPORATION (US) 1988-01-19 US disclosed
US-4692551-A SALT FORMATION OF ALCOHOL ETHER WITH METAL HYDROXIDE, REACTING SALT WITH A BUTYROLACTONE GAF CORPORATION (US) 1987-09-08 US disclosed