Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9508895 | 0.85 | — | — | |
| SCHEMBL9508244 | 0.85 | BTK (0.48) | SRC | |
| SCHEMBL9508947 | 0.82 | — | — | |
| SCHEMBL9510869 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL9776804 | 0.77 | — | — | |
| SCHEMBL9509700 | 0.75 | MEN1 (0.50) | — | |
| SCHEMBL9776757 | 0.75 | SLC2A1 (0.48) | — | |
| SCHEMBL9508913 | 0.75 | HTR1B (0.49) | — | |
| SCHEMBL9510898 | 0.74 | — | — | |
| SCHEMBL9508882 | 0.73 | SLC2A1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0404322-B1 | QUINAZOLINE DERIVATIVES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-09-22 | — | — | EP | claimed |
| EP-0404322-B1 | QUINAZOLINE DERIVATIVES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-09-22 | — | — | EP | disclosed |
| US-5064833-A | Substituted quinazoline derivatives for use in gastrointestinal diseases | SMITHKLINE BEECHAM INTERCREDIT B.V. (GB) | 1991-11-12 | — | — | US | disclosed |
| EP-0404322-A1 | Quinazoline derivatives | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1990-12-27 | — | — | EP | disclosed |