SCHEMBL9511294

SCHEMBL9511294

CCc1ccc(CCc2ccc(C#Cc3ccc(C)cc3)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 7/20 0.58
CYP2A6 P11509 2/20 0.48
KCNH2 Q12809 3/20 0.46
TAAR1 Q96RJ0 2/20 0.45
CYP1A2 P05177 1/20 0.45
GRM5 P41594 1/20 0.44
ACACB O00763 2/20 0.42
CHKA P35790 1/20 0.42
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7503100 0.94 CYP2A6 (0.54) FFAR1CYP2A6KCNH2TAAR1CYP1A2
SCHEMBL9328231 0.94 CYP2A6 (0.54) FFAR1CYP2A6KCNH2TAAR1CYP1A2
SCHEMBL9509240 0.91 CYP2A6 (0.56) FFAR1CYP2A6TAAR1ACACB
SCHEMBL9512262 0.88 FFAR1 (0.58) FFAR1CYP2A6KCNH2TAAR1CYP1A2
SCHEMBL6546215 0.87 TAAR1 (0.56) CYP2A6KCNH2TAAR1CYP1A2CHKA
SCHEMBL10510748 0.85 HSD17B10 (0.45) FFAR1KCNH2ACACB
SCHEMBL10510758 0.85 HSD17B10 (0.45) FFAR1KCNH2ACACB
SCHEMBL10512143 0.85 HSD17B10 (0.45) FFAR1KCNH2ACACB
SCHEMBL10512200 0.85 HSD17B10 (0.45) FFAR1KCNH2ACACB
SCHEMBL9349697 0.85 FFAR1 (0.59) FFAR1CYP2A6KCNH2TAAR1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0308438-B1 LIQUID CRYSTAL PHASE CONTAINING TOLANES MERCK PATENT GmbH (DE) 1993-09-29 EP disclosed