Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.64 |
| ▸ | IL1RN | P18510 | 2/20 | 0.64 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.44 |
| ▸ | VEGFA | P15692 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9511617 | 1.00 | ERAP2 (0.64) | ERAP2IL1RNERAP1KDM4EEGLN1 | |
| SCHEMBL8102437 | 0.90 | ERAP2 (0.60) | ERAP2IL1RNERAP1KDM4EMAPT | |
| SCHEMBL10966257 | 0.87 | ERAP2 (0.63) | ERAP2IL1RNERAP1KDM4EEGLN1 | |
| SCHEMBL8100239 | 0.87 | ERAP2 (0.63) | ERAP2IL1RNERAP1KDM4EEGLN1 | |
| SCHEMBL9385864 | 0.85 | ERAP2 (0.62) | ERAP2IL1RNERAP1KDM4EEGLN1 | |
| SCHEMBL9511620 | 0.85 | ERAP2 (0.56) | ERAP2IL1RNERAP1KDM4EEGLN1 | |
| SCHEMBL8102037 | 0.83 | ERAP2 (0.59) | ERAP2IL1RNERAP1KDM4EEGLN1 | |
| SCHEMBL8102285 | 0.80 | ERAP2 (0.54) | ERAP2IL1RNERAP1EGLN1VEGFA | |
| SCHEMBL8132096 | 0.79 | ERAP2 (0.54) | ERAP2IL1RNERAP1MAPTLMNA | |
| SCHEMBL8268683 | 0.75 | ERAP2 (0.78) | ERAP2IL1RNERAP1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357150-B1 | Pharmaceutical compositions | BRITISH TECH GROUP (GB) | 1993-12-08 | — | — | EP | disclosed |
| US-5104865-A | IRON COMPLEXES OF HYDROXYPYRIDONES USEFUL FOR TREATING IRON OVERLOAD | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1992-04-14 | — | — | US | disclosed |
| US-4912118-A | Therapy for toxic concentration of metal | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-03-27 | — | — | US | disclosed |
| EP-0138421-A2 | Hydroxypyridone derivatives and pharmaceutical compositions containing them | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1985-04-24 | — | — | EP | disclosed |