Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16625507 | 1.00 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL9515266 | 0.95 | HTT (0.67) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL8106191 | 0.90 | HTT (0.70) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL8108280 | 0.88 | HTT (0.67) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL30982572 | 0.87 | MEN1 (0.68) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL30982687 | 0.87 | MEN1 (0.68) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL30982746 | 0.87 | MEN1 (0.68) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL8108601 | 0.87 | HTT (0.68) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL6327211 | 0.87 | MEN1 (0.68) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL8102028 | 0.85 | HTT (0.70) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357150-B1 | Pharmaceutical compositions | BRITISH TECH GROUP (GB) | 1993-12-08 | — | — | EP | disclosed |
| US-5104865-A | IRON COMPLEXES OF HYDROXYPYRIDONES USEFUL FOR TREATING IRON OVERLOAD | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1992-04-14 | — | — | US | disclosed |
| EP-0138421-B1 | HYDROXYPYRIDONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-12-05 | — | — | EP | disclosed |
| US-4912118-A | Therapy for toxic concentration of metal | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-03-27 | — | — | US | disclosed |
| EP-0357150-A1 | Pharmaceutical compositions | BTG INTERNATIONAL LIMITED (GB) | 1990-03-07 | — | — | EP | disclosed |
| EP-0138421-A2 | Hydroxypyridone derivatives and pharmaceutical compositions containing them | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1985-04-24 | — | — | EP | disclosed |