Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GLRA1 | P23415 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28060142 | 0.78 | GLRA1 (0.60) | GLRA1ALDH1A1PPARGL3MBTL1LMNA | |
| SCHEMBL28060106 | 0.78 | GLRA1 (0.60) | GLRA1ALDH1A1PPARGL3MBTL1LMNA | |
| SCHEMBL28060114 | 0.78 | GLRA1 (0.60) | GLRA1ALDH1A1PPARGL3MBTL1LMNA | |
| SCHEMBL10591282 | 0.76 | POLB (0.52) | POLBALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL27794250 | 0.75 | PTGER1 (0.48) | GLRA1ALDH1A1PPARGL3MBTL1LMNA | |
| SCHEMBL10963748 | 0.74 | POLB (0.50) | POLBALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL8682572 | 0.73 | BRD4 (0.51) | GLRA1ALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL8323310 | 0.73 | BRD4 (0.51) | GLRA1ALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL10964174 | 0.72 | PTGER4 (0.55) | POLBPPARGL3MBTL1NSD2ABL1 | |
| SCHEMBL28739338 | 0.72 | GLRA1 (0.47) | GLRA1ALDH1A1L3MBTL1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357150-B1 | Pharmaceutical compositions | BRITISH TECH GROUP (GB) | 1993-12-08 | — | — | EP | disclosed |
| US-5104865-A | IRON COMPLEXES OF HYDROXYPYRIDONES USEFUL FOR TREATING IRON OVERLOAD | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1992-04-14 | — | — | US | disclosed |
| EP-0138421-B1 | HYDROXYPYRIDONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-12-05 | — | — | EP | disclosed |
| US-4912118-A | Therapy for toxic concentration of metal | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-03-27 | — | — | US | disclosed |
| EP-0357150-A1 | Pharmaceutical compositions | BTG INTERNATIONAL LIMITED (GB) | 1990-03-07 | — | — | EP | disclosed |