Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.63 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.62 |
| ▸ | TACR1 | P25103 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | TYR | P14679 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514554 | 1.00 | ACE (0.63) | ACEMBTPS1TACR1POLBTYR | |
| SCHEMBL13819263 | 0.88 | ACE (0.63) | ACEMBTPS1TACR1POLBTYR | |
| SCHEMBL9385728 | 0.87 | TP53 (0.60) | TACR1POLBALDH1A1CYP2C9THRB | |
| SCHEMBL9146866 | 0.87 | TP53 (0.60) | TACR1POLBALDH1A1CYP2C9THRB | |
| SCHEMBL9146870 | 0.87 | TP53 (0.60) | TACR1POLBALDH1A1CYP2C9THRB | |
| SCHEMBL9385733 | 0.87 | TP53 (0.60) | TACR1POLBALDH1A1CYP2C9THRB | |
| SCHEMBL18515876 | 0.87 | ACE (0.62) | ACEMBTPS1TACR1POLBTYR | |
| SCHEMBL30516239 | 0.87 | ACE (0.62) | ACEMBTPS1TACR1POLBTYR | |
| SCHEMBL18429658 | 0.87 | ACE (0.62) | ACEMBTPS1TACR1POLBTYR | |
| SCHEMBL13296315 | 0.87 | TACR1 (0.64) | ACEMBTPS1TACR1POLBTYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266950-B1 | Nor-statine and nor-cyclostatine polypeptides | PFIZER (US) | 1993-12-29 | — | — | EP | disclosed |
| US-5034376-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4935405-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4814342-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0266950-A2 | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1988-05-11 | — | — | EP | disclosed |