Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP4 | P49662 | 1/20 | 0.57 |
| ▸ | CASP5 | P51878 | 1/20 | 0.57 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1509517 | 0.94 | POLB (1.00) | POLBALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL3151686 | 0.86 | POLB (0.71) | POLBALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL3439980 | 0.85 | POLB (0.73) | POLBALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL25368316 | 0.84 | POLB (0.73) | POLBALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL15347670 | 0.84 | POLB (0.73) | POLBALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL11556051 | 0.83 | POLB (0.71) | POLBALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL11550138 | 0.83 | POLB (0.75) | POLBALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL11551844 | 0.83 | POLB (0.71) | POLBALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL11549718 | 0.83 | POLB (0.71) | POLBALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL1126947 | 0.83 | POLB (0.75) | POLBALDH1A1MAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233051-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1993-09-15 | — | — | EP | disclosed |
| US-4806536-A | Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents | PFIZER, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0233051-A2 | Antiarrhythmic Agents | Pfizer Limited (GB) | 1987-08-19 | — | — | EP | disclosed |