Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 3/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515057 | 1.00 | ANPEP (0.53) | ANPEPKDM1ADPP4ALDH1A1KDM4E | |
| SCHEMBL9515050 | 1.00 | ANPEP (0.53) | ANPEPKDM1ADPP4ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9516290 | 0.98 | ANPEP (0.51) | ANPEPKDM1ADPP4ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9516294 | 0.98 | ANPEP (0.51) | ANPEPKDM1ADPP4ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9516301 | 0.98 | ANPEP (0.51) | ANPEPKDM1ADPP4ALDH1A1KDM4E | |
| SCHEMBL6990855 | 0.73 | KDM4E (0.57) | ANPEPALDH1A1KDM4EGLAGAA | |
| SCHEMBL11355392 | 0.72 | ANPEP (0.68) | ANPEP | |
| SCHEMBL9515317 | 0.72 | ANPEP (0.68) | ANPEP | |
| SCHEMBL3996873 | 0.72 | ANPEP (0.68) | ANPEP | |
| SCHEMBL30070669 | 0.72 | ANPEP (0.68) | ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0378456-B1 | TETRALIN DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5106861-A | Method of using certain tetralin derivatives to produce analgesic relief | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-21 | — | — | US | disclosed |
| US-5041673-A | Aminopeptidase inhibitors, immunomodulators, analgesics | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |
| EP-0378456-A1 | Tetralin derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-07-18 | — | — | EP | disclosed |