Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 20/20 | 0.78 |
| ▸ | CA2 | P00918 | 20/20 | 0.78 |
| ▸ | CA4 | P22748 | 2/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13685900 | 0.80 | CA1 (0.67) | CA1CA2CA4CA12CA9 | |
| SCHEMBL8971332 | 0.75 | CA1 (0.59) | CA1CA2CA4CA12CA9 | |
| SCHEMBL13685901 | 0.74 | CA1 (0.57) | CA1CA2CA4CA12CA9 | |
| SCHEMBL13685893 | 0.73 | CA1 (0.56) | CA1CA2CA4CA12CA9 | |
| SCHEMBL10957440 | 0.73 | CA1 (0.58) | CA1CA2CA4CA12CA9 | |
| SCHEMBL13685995 | 0.73 | CA1 (0.60) | CA1CA2CA4CA12CA9 | |
| SCHEMBL9699754 | 0.73 | CA1 (0.50) | CA1CA2CA4CA12CA9 | |
| SCHEMBL3867150 | 0.72 | CA1 (0.55) | CA1CA2CA4CA12CA9 | |
| SCHEMBL5014186 | 0.69 | CA1 (0.70) | CA1CA2CA4CA12CA9 | |
| SCHEMBL9514425 | 0.68 | CA1 (0.63) | CA1CA2CA4CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539527-A1 | ANALOGS OF CARBONIC ANHYDRASE INHIBITORS AND THEIR USE AS TOPICAL IOP INHIBITORS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1993-05-05 | — | — | EP | disclosed |
| US-5157044-A | Treating glaucoma | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1992-10-20 | — | — | US | disclosed |
| US-5095026-A | PRODRUGS OF CARBONIC ANHYDRASE INHIBITORS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1992-03-10 | — | — | US | disclosed |
| WO-1992000287-A2 | ANALOGS OF CARBONIC ANHYDRASE INHIBITORS AND THEIR USE AS TOPICAL IOP INHIBITORS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1992-01-09 | — | — | WO | disclosed |