Histidine

Histidine

SCHEMBL951652

N[C@@H](Cc1c[nH]cn1)C(=O)[O-].N[C@@H](Cc1c[nH]cn1)C(=O)[O-].[Co+2]

nearest known ligand 0.32

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.32
SLC7A5 Q01650 1/20 0.32
CYP1A2 P05177 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL8161511 0.98 CYP3A4 (0.33) CYP3A4SLC7A5CYP1A2
Histidine SCHEMBL8161515 0.97 CYP3A4 (0.32) CYP3A4SLC7A5CYP1A2
Histidine SCHEMBL5067274 0.97 CYP3A4 (0.32) CYP3A4SLC7A5CYP1A2
Histidine SCHEMBL7782135 0.97 CYP3A4 (0.32) CYP3A4SLC7A5CYP1A2
Histidine SCHEMBL3739430 0.97 CYP3A4 (0.32) CYP3A4SLC7A5CYP1A2
Histidine SCHEMBL11881302 0.97 CYP3A4 (0.32) CYP3A4SLC7A5CYP1A2
Histidine SCHEMBL15018457 0.97 CYP3A4 (0.32) CYP3A4SLC7A5CYP1A2
Histidine SCHEMBL15017944 0.97 CYP3A4 (0.32) CYP3A4SLC7A5CYP1A2
Histidine SCHEMBL17473905 0.97 CYP3A4 (0.32) CYP3A4SLC7A5CYP1A2
Histidine SCHEMBL12537934 0.97 CYP3A4 (0.32) CYP3A4SLC7A5CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7896935-B2 Process of conducting reactions or separation in a microchannel with internal fin support for catalyst or sorption medium VELOCYS, INC. (US) 2011-03-01 US claimed
US-20070140955-A1 MICROCHANNEL WITH INTERNAL FIN SUPPORT FOR CATALYST OR SORPTION MEDIUM TONKOVICH ANNA L 2007-06-21 US claimed
US-7220390-B2 Microchannel with internal fin support for catalyst or sorption medium VELOCYS, INC. (US) 2007-05-22 US claimed
US-20040228781-A1 chemical reactors having microstructure passageways, catalysts supports, absorber materials and heat exchangers VELOCYS, INC. 2004-11-18 US claimed
US-6652627-B1 Process for separating a fluid component from a fluid mixture using microchannel process technology VELOCYS, INC. 2003-11-25 US claimed
JP-1242124-A None JP disclosed
US-8580211-B2 Microchannel with internal fin support for catalyst or sorption medium VELOCYS, INC. (US) 2013-11-12 US disclosed
EP-2463024-A1 Microchannel with internal fin support for catalyst or sorption medium Velocys Inc. (US) 2012-06-13 EP disclosed
US-7896935-B2 Process of conducting reactions or separation in a microchannel with internal fin support for catalyst or sorption medium VELOCYS, INC. (US) 2011-03-01 US disclosed
EP-1562688-B1 PROCESS FOR SEPARATING A FLUID COMPONENT FROM A FLUID MIXTURE BY SORPTION USING MICROCHANNEL PROCESS TECHNOLOGY VELOCYS INC (US) 2011-02-09 EP disclosed
US-20110002818-A1 MICROCHANNEL WITH INTERNAL FIN SUPPORT FOR CATALYST OR SORPTION MEDIUM TONKOVICH ANNA LEE 2011-01-06 US disclosed
US-20070140955-A1 MICROCHANNEL WITH INTERNAL FIN SUPPORT FOR CATALYST OR SORPTION MEDIUM TONKOVICH ANNA L 2007-06-21 US disclosed
US-6989195-B2 Coated particles, methods of making and using LYOTROPIC THERAPEUTICS, INC. (US) 2006-01-24 US disclosed
US-20040228781-A1 chemical reactors having microstructure passageways, catalysts supports, absorber materials and heat exchangers VELOCYS, INC. 2004-11-18 US disclosed
US-20030235577-A1 Methods and compositions for preventing and treating microbial infections NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-12-25 US disclosed
US-6652627-B1 Process for separating a fluid component from a fluid mixture using microchannel process technology VELOCYS, INC. 2003-11-25 US disclosed
WO-2003087325-A2 METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING MICROBIAL INFECTIONS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2003-10-23 WO disclosed
JP-H01242124-A GAS-SEPARATING MEMBRANE AGENCY OF IND SCIENCE & TECHNOL 1989-09-27 JP disclosed
US-4322390-A Hydrometallurgical recovery of copper, cobalt nickel with reductive and oxidative leaching UOP INC. (US) 1982-03-30 US disclosed
US-4081509-A Method for removing nitrogen oxides from flue gas by absorption HITACHI, LTD. (JA) 1978-03-28 US disclosed