Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 9/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518302 | 0.89 | HMGCR (0.66) | HMGCR | |
| SCHEMBL9750860 | 0.87 | HMGCR (0.78) | HMGCR | |
| SCHEMBL9750927 | 0.85 | HMGCR (0.66) | HMGCR | |
| SCHEMBL9518920 | 0.79 | HMGCR (0.67) | HMGCR | |
| SCHEMBL8949666 | 0.79 | HMGCR (0.44) | HMGCR | |
| SCHEMBL9750882 | 0.78 | HMGCR (1.00) | HMGCR | |
| SCHEMBL27312221 | 0.78 | HMGCR (0.44) | HMGCR | |
| SCHEMBL9521396 | 0.77 | HMGCR (0.68) | HMGCR | |
| SCHEMBL6962901 | 0.77 | HMGCR (0.49) | HMGCR | |
| SCHEMBL9521423 | 0.77 | HMGCR (0.79) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300249-B1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-03 | — | — | EP | disclosed |
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |
| EP-0300249-A1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-25 | — | — | EP | disclosed |