Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 15/20 | 0.47 |
| ▸ | TOP2B | Q02880 | 15/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520197 | 0.88 | TOP2A (0.60) | TOP2ATOP2BKCNH2GSK3B | |
| SCHEMBL10876273 | 0.81 | TOP2A (0.48) | TOP2ATOP2BKCNH2 | |
| SCHEMBL9048001 | 0.81 | TOP2A (0.46) | TOP2ATOP2BKCNH2GSK3B | |
| SCHEMBL9671579 | 0.78 | TOP2A (0.45) | TOP2ATOP2BKCNH2 | |
| SCHEMBL7821385 | 0.78 | KDM4E (0.54) | TOP2ATOP2BKCNH2 | |
| SCHEMBL6213861 | 0.78 | TOP2A (0.52) | TOP2ATOP2BKCNH2GSK3B | |
| SCHEMBL9668073 | 0.78 | KCNH2 (0.47) | TOP2ATOP2BKCNH2 | |
| SCHEMBL10811238 | 0.78 | KCNH2 (0.47) | TOP2ATOP2BKCNH2 | |
| Hydrochloric Acid SCHEMBL10502571 | 0.78 | KDM4E (0.53) | TOP2ATOP2BKCNH2 | |
| SCHEMBL10807064 | 0.77 | TOP2A (0.51) | TOP2ATOP2BKCNH2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0340055-B1 | 7-(1-IMIDAZOLYL)-1,4-DIHYDRO-4-OXO-6,8-DIFLUORO-1-CYCLOPROPYL QUINOLINECARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1993-03-10 | — | — | EP | claimed |