Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | FGB | P02675 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519911 | 1.00 | PTAFR (0.42) | PTAFRSLC6A4SLC6A2SLC6A3HSP90AA1 | |
| SCHEMBL9519919 | 1.00 | PTAFR (0.42) | PTAFRSLC6A4SLC6A2SLC6A3HSP90AA1 | |
| Water SCHEMBL9522425 | 0.98 | PTAFR (0.41) | PTAFRSLC6A4SLC6A2SLC6A3HSP90AA1 | |
| SCHEMBL21401005 | 0.79 | SLC6A2 (0.41) | SLC6A4SLC6A2SLC6A3P2RX7HTR2A | |
| SCHEMBL18661258 | 0.79 | CYP2A6 (0.43) | PTAFRP2RX7NOS3NOS1NOS2 | |
| SCHEMBL9522247 | 0.77 | HRH1 (0.49) | P2RX7NOS3NOS1NOS2MAOA | |
| SCHEMBL3827608 | 0.77 | GRM5 (0.41) | PTAFRALDH1A1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL29857658 | 0.77 | GRM5 (0.41) | PTAFRALDH1A1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL30720899 | 0.75 | TDP1 (0.46) | TDP1KCNH2 | |
| SCHEMBL31141498 | 0.75 | GRM5 (0.40) | PTAFRALDH1A1RAB9ASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| US-4975438-A | ANTICOAGULANT | HOFFMANN-LA ROCHE INC. (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |
| US-4788206-A | CARDIOVASCULAR DISORDERS, PLATELETS | HOFFMANN-LA ROCHE INC. (US) | 1988-11-29 | — | — | US | disclosed |