Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 16/20 | 0.43 |
| ▸ | PPARA | Q07869 | 13/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9523616 | 0.84 | FFAR1 (0.42) | PPARGPPARAFFAR1 | |
| SCHEMBL4185581 | 0.84 | PPARG (0.44) | PPARGPPARAKDM4ECYP3A4CYP2C9 | |
| Darglitazone SCHEMBL9436449 | 0.84 | PPARG (0.48) | PPARGPPARAKDM4ECYP3A4CYP2C9 | |
| Darglitazone SCHEMBL20125582 | 0.84 | PPARG (0.48) | PPARGPPARAKDM4ECYP3A4CYP2C9 | |
| Darglitazone SCHEMBL37497 | 0.84 | PPARG (0.48) | PPARGPPARAKDM4ECYP3A4CYP2C9 | |
| Darglitazone SCHEMBL674635 | 0.84 | PPARG (0.48) | PPARGPPARAKDM4ECYP3A4CYP2C9 | |
| SCHEMBL7719068 | 0.81 | PPARG (0.43) | PPARGPPARAKDM4ECYP3A4CYP2C9 | |
| SCHEMBL13451557 | 0.79 | PPARG (0.48) | PPARGPPARAPPARD | |
| SCHEMBL9721218 | 0.78 | PPARG (0.55) | PPARGPPARA | |
| Darglitazone SCHEMBL16554324 | 0.78 | PPARG (0.44) | PPARGPPARACYP3A4CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332332-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5130379-A | Anticholesterol agents and antidiabetic agents | PFIZER INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5036079-A | Anticholesterol | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| WO-1991003474-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1991-03-21 | — | — | WO | disclosed |
| EP-0332332-A1 | Hypoglycemic thiazolidinedione derivatives | PFIZER INC. (US) | 1989-09-13 | — | — | EP | disclosed |