Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 19/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1811551 | 0.93 | ALOX5AP (0.60) | ALOX5APALOX5CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9522220 | 0.89 | ALOX5AP (0.49) | ALOX5APALOX5CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9043392 | 0.88 | ALOX5AP (0.43) | ALOX5APALOX5CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9521164 | 0.88 | ALOX5AP (0.50) | ALOX5APALOX5CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2589634 | 0.83 | ALOX5AP (0.51) | ALOX5APALOX5CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9388578 | 0.83 | ALOX5AP (0.52) | ALOX5APALOX5CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9387633 | 0.82 | ALOX5AP (0.51) | ALOX5APALOX5CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9388581 | 0.81 | ALOX5AP (0.52) | ALOX5APALOX5CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9212984 | 0.79 | ALOX5AP (0.51) | ALOX5APALOX5CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9387682 | 0.77 | ALOX5AP (0.52) | ALOX5APALOX5CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544819-A4 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS | — | 1993-10-20 | — | — | EP | disclosed |
| EP-0544819-A1 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS. | ABBOTT LAB (US) | 1993-06-09 | — | — | EP | disclosed |