Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | BCHE | P06276 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.65 |
| ▸ | RELA | Q04206 | 1/20 | 0.65 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.64 |
| ▸ | MAOB | P27338 | 3/20 | 0.61 |
| ▸ | P4HB | P07237 | 2/20 | 0.60 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.58 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.58 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.58 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520743 | 1.00 | MAPT (0.73) | MAPTALDH1A1LMNAL3MBTL1BCHE | |
| SCHEMBL14318031 | 0.90 | ABCG2 (0.80) | MAPTALDH1A1LMNAL3MBTL1BCHE | |
| SCHEMBL8987059 | 0.87 | BCHE (0.78) | MAPTALDH1A1LMNABCHECYP3A4 | |
| SCHEMBL8987057 | 0.87 | BCHE (0.78) | MAPTALDH1A1LMNABCHECYP3A4 | |
| SCHEMBL14306001 | 0.86 | ABCG2 (0.82) | MAPTALDH1A1LMNAL3MBTL1BCHE | |
| SCHEMBL8987364 | 0.85 | MAPT (1.00) | MAPTALDH1A1LMNAL3MBTL1BCHE | |
| SCHEMBL3359288 | 0.85 | MAPT (1.00) | MAPTALDH1A1LMNAL3MBTL1BCHE | |
| SCHEMBL14318118 | 0.84 | F3 (0.77) | MAPTALDH1A1LMNAL3MBTL1BCHE | |
| SCHEMBL27903979 | 0.84 | F3 (0.77) | MAPTALDH1A1LMNAL3MBTL1BCHE | |
| SCHEMBL15807423 | 0.82 | ABCG2 (0.68) | MAPTALDH1A1LMNAL3MBTL1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540604-A1 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | Aventis Pharma S.A. (FR) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001675-A2 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | RHONE-POULENC RORER S.A. (FR) | 1992-02-06 | — | — | WO | disclosed |