Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 6/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.36 |
| ▸ | ITGAV | P06756 | 5/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14348092 | 0.86 | ABCB1 (0.42) | ABCB1POLBPDK1PDK2PDK3 | |
| SCHEMBL9639974 | 0.85 | ABCB1 (0.41) | ABCB1POLBPDK1PDK2PDK3 | |
| SCHEMBL18962 | 0.84 | ABCB1 (0.43) | ABCB1POLBPDK1PDK2PDK3 | |
| SCHEMBL15958482 | 0.84 | ABCB1 (0.43) | ABCB1POLBPDK1PDK2PDK3 | |
| SCHEMBL9370028 | 0.84 | ABCB1 (0.43) | ABCB1POLBPDK1PDK2PDK3 | |
| SCHEMBL9026282 | 0.84 | ABCB1 (0.43) | ABCB1POLBPDK1PDK2PDK3 | |
| SCHEMBL8833139 | 0.84 | ABCB1 (0.43) | ABCB1POLBPDK1PDK2PDK3 | |
| SCHEMBL9370027 | 0.84 | ABCB1 (0.43) | ABCB1POLBPDK1PDK2PDK3 | |
| SCHEMBL29254 | 0.84 | ABCB1 (0.43) | ABCB1POLBPDK1PDK2PDK3 | |
| SCHEMBL9369164 | 0.83 | ABCB1 (0.40) | ABCB1POLBPDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272456-B1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-31 | — | — | EP | disclosed |
| US-4822787-A | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid compounds and antimicrobial activity thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0272456-A1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-29 | — | — | EP | disclosed |