Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | TOP2A | P11388 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 4/20 | 0.67 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.67 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.67 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15112706 | 0.86 | CYP3A4 (0.78) | CYP3A4SMN1; SMN2TOP2AGAATOP2B | |
| SCHEMBL12232187 | 0.86 | CYP3A4 (0.78) | CYP3A4SMN1; SMN2TOP2AGAATOP2B | |
| SCHEMBL16436129 | 0.86 | CYP3A4 (0.78) | CYP3A4SMN1; SMN2TOP2AGAATOP2B | |
| Teniposide SCHEMBL13809319 | 0.81 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2TOP2AGAATOP2B | |
| Teniposide SCHEMBL14008692 | 0.81 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2TOP2AGAATOP2B | |
| Teniposide SCHEMBL23202938 | 0.81 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2TOP2AGAATOP2B | |
| Teniposide SCHEMBL94844 | 0.81 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2TOP2AGAATOP2B | |
| Teniposide SCHEMBL12278906 | 0.81 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2TOP2AGAATOP2B | |
| Teniposide SCHEMBL14031677 | 0.81 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2TOP2AGAATOP2B | |
| Teniposide SCHEMBL13712547 | 0.81 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2TOP2AGAATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058112-A1 | ANTIBODIES | MERCK SHARP & DOHME CORP. | 2012-03-08 | — | — | US | disclosed |
| US-20120058112-A1 | ANTIBODIES | MERCK SHARP & DOHME CORP. | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058112-A1 | ANTIBODIES | IGF1R, EGFR, ERBB3 | CYP3A4 4577/4885SMN1; SMN2 1795/4885TOP2A 2073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.