SCHEMBL9522345

SCHEMBL9522345

NCCCc1cccc2ccncc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.46
TNF P01375 2/20 0.44
TLR8 Q9NR97 4/20 0.43
TRPV1 Q8NER1 1/20 0.42
HTR6 P50406 1/20 0.41
HRH1 P35367 3/20 0.40
CYP2D6 P10635 3/20 0.40
CYP3A4 P08684 2/20 0.40
CYP1A2 P05177 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
LMNA P02545 1/20 0.40
KDM4E B2RXH2 1/20 0.40
MAPKAPK2 P49137 1/20 0.40
SSTR2 P30874 1/20 0.38
SSTR4 P31391 1/20 0.38
MEN1 O00255 1/20 0.38
PRKD3 O94806 1/20 0.38
TP53 P04637 1/20 0.38
PRKCG P05129 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6114803 0.83 TNF (0.44) TNFTLR8TRPV1LMNAKDM4E
SCHEMBL9519383 0.83 TNF (0.47) TNFTLR8TRPV1CYP2D6CYP3A4
SCHEMBL31742311 0.82 TNF (0.49) CYP2A6TNFTRPV1CYP2D6CYP3A4
SCHEMBL4785840 0.82 TNF (0.49) CYP2A6TNFTRPV1CYP2D6CYP3A4
SCHEMBL6115311 0.82 TDP1 (0.47) TNFTLR8TRPV1
SCHEMBL21178923 0.82 TNF (0.42) TNFTRPV1CYP2D6CYP3A4CYP1A2
SCHEMBL6115070 0.81 TDP1 (0.46) TNFTLR8TRPV1
SCHEMBL6114865 0.81 TDP1 (0.46) TNFTLR8TRPV1
SCHEMBL6114591 0.81 TDP1 (0.46) TNFTLR8TRPV1
SCHEMBL6114546 0.81 TDP1 (0.46) TNFTLR8TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0299379-B1 PENTADIENAMIDE PAF-ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 1993-04-21 EP disclosed
US-4975438-A ANTICOAGULANT HOFFMANN-LA ROCHE INC. (US) 1990-12-04 US disclosed
US-4927838-A CARDIOVASCULAR DISORDERS HOFFMAN-LA ROCHE INC. (US) 1990-05-22 US disclosed
US-4927826-A Cycloproylpropenamides useful as platelet activing factor (PAF) antagonists HOFFMAN-LA ROCHE INC. (US) 1990-05-22 US disclosed
US-4916145-A PLATELET ACTIVATING FACTOR ANTAGONISTS HOFFMANN-LA ROCHE INC. (US) 1990-04-10 US disclosed
EP-0299379-A1 Pentadienamide PAF-antagonists F. HOFFMANN-LA ROCHE AG (CH) 1989-01-18 EP disclosed
US-4788206-A CARDIOVASCULAR DISORDERS, PLATELETS HOFFMANN-LA ROCHE INC. (US) 1988-11-29 US disclosed
US-4786646-A PLATELET ACTIVATING FACTOR ANTAGONISTS HOFFMANN-LA ROCHE INC. (US) 1988-11-22 US disclosed