Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.32 |
| ▸ | PIK3R5 | Q8WYR1 | 3/20 | 0.32 |
| ▸ | PIK3R3 | Q92569 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522441 | 0.93 | TP53 (0.44) | TP53MAPTLMNAKMT2APIK3CD | |
| SCHEMBL9522233 | 0.90 | KMT2A (0.44) | TP53MAPTLMNAKMT2APIK3CD | |
| SCHEMBL9523890 | 0.89 | TP53 (0.35) | TP53MAPTLMNAKMT2APIK3CD | |
| SCHEMBL9175534 | 0.87 | NTRK1 (0.34) | MAPTNTRK1NTRK2MAPK13MAPK12 | |
| SCHEMBL9523089 | 0.87 | TP53 (0.38) | TP53MAPTLMNA | |
| SCHEMBL9523104 | 0.87 | TP53 (0.35) | TP53MAPTNTRK1NTRK2LMNA | |
| SCHEMBL9316680 | 0.86 | MAPT (0.45) | TP53MAPTLMNAPIK3CDPIK3R2 | |
| SCHEMBL9522373 | 0.86 | AURKB (0.34) | TP53MAPTLMNAMAPK14PIK3CD | |
| SCHEMBL9831789 | 0.86 | TP53 (0.41) | TP53MAPTMAPK13MAPK12MAPK11 | |
| SCHEMBL9523673 | 0.85 | TP53 (0.35) | TP53MAPTLMNAMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420883-B1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5166152-A | Immunostimulants, bactericides, viricides, antitumor agents | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-11-24 | — | — | US | disclosed |
| EP-0420883-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1991-04-10 | — | — | EP | disclosed |
| WO-1989012638-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |