Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 17/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9523381 | 1.00 | PTAFR (0.59) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL9522236 | 1.00 | PTAFR (0.59) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL10464293 | 1.00 | PTAFR (0.59) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL10465293 | 0.92 | PTAFR (0.62) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL9522870 | 0.92 | PTAFR (0.62) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL9522364 | 0.91 | PTAFR (0.56) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL9525233 | 0.91 | PTAFR (0.56) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL10464198 | 0.91 | PTAFR (0.58) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL9521990 | 0.90 | PTAFR (0.57) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL9523433 | 0.90 | PTAFR (0.57) | PTAFROPRK1PDE4DCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315698-B1 | THIENO(TRIAZOLO)DIAZEPINE COMPOUNDS AND MEDICINAL APPLICATION OF THE SAME | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| US-4960770-A | Vasodilating agents, cardiovascular disorder | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1990-10-02 | — | — | US | disclosed |
| EP-0315698-A1 | THIENO(TRIAZOLO)DIAZEPINE COMPOUNDS AND MEDICINAL APPLICATION OF THE SAME | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1989-05-17 | — | — | EP | disclosed |